Novo Nordisk is discontinuing Rybelsus® and replacing it with Ozempic® tablets, also called the Ozempic pill. Both medications contain the same active ingredient—semaglutide—and are used to help adults with type 2 diabetes manage their blood sugar.
Although the name and tablet strengths are changing, Ozempic tablets provide the same type of treatment as Rybelsus. However, the Ozempic pill is not the same as the once-weekly Ozempic injection.
What is staying the same?
Rybelsus and the Ozempic pill contain the same active ingredient, semaglutide. Both are once-daily tablets approved for adults with type 2 diabetes. The instructions for taking them are also similar.
What is changing?
Rybelsus tablets are available in 3 mg, 7 mg, and 14 mg strengths. Ozempic tablets use a newer formulation and come in 1.5 mg, 4 mg, and 9 mg strengths.
Because the formulations are different, the doses are not interchangeable milligram for milligram. According to the FDA-approved prescribing information, patients who have completed the initial 30-day treatment period may generally transition as follows:
| Current Rybelsus dose | Corresponding Ozempic tablet dose |
|---|---|
| Rybelsus 7 mg | Ozempic tablet 4 mg |
| Rybelsus 14 mg | Ozempic tablet 9 mg |
⚠️ Important dosing warning
Do not choose an Ozempic tablet dose based only on the number of milligrams. The products are not interchangeable milligram for milligram. Your doctor must determine the appropriate dose and when you should make the change.
Possible benefits of the change
- The active ingredient remains the same. Both medications contain semaglutide and have the same approved uses for adults with type 2 diabetes.
- No injection is required. The Ozempic pill continues to provide an oral option for people who prefer tablets.
- Your copay may be lower. Ozempic has a lower copay than Rybelsus on many Medicare Part D plans.
- The Ozempic name may be more familiar. Bringing the pill and injection under the same brand may make semaglutide treatment options easier to recognize.
? HeyMOE Tip: Check your Part D copay
Ozempic may cost less than Rybelsus under your Medicare Part D plan, but every plan is different. Check the medication’s formulary tier, preferred pharmacy price, prior-authorization requirements, and estimated copay before filling your new prescription.
Possible drawbacks or concerns
- You may need a new prescription. Your pharmacy may not be able to substitute Ozempic tablets automatically.
- The tablet strengths are different. A lower number on the Ozempic tablet does not mean the medication is weaker.
- Insurance requirements may change. Your plan could require prior authorization, step therapy, or a formulary exception—even if the copay is lower.
- The Ozempic name could cause confusion. Ozempic is available as both a daily pill and a weekly injection. Check your prescription carefully to see which form your doctor ordered.
- Semaglutide side effects and precautions still apply. Changing the brand name does not eliminate the medication’s potential risks or side effects.
? Do not change medications on your own
Do not stop Rybelsus or begin taking an Ozempic pill without instructions from your doctor. Contact your prescriber early so you have the correct prescription before your current supply runs out.
? HeyMOE Tip: Avoid a gap in treatment
Contact your doctor and Part D plan before your Rybelsus supply runs out. This gives you time to obtain a new prescription, complete any required prior authorization, and locate a pharmacy that has the Ozempic tablets available.
Have more questions?
If you have questions about the transition from Rybelsus to the Ozempic pill, contact your doctor or pharmacist. They can help you make the change safely and answer questions about your dose, side effects, and blood sugar.
For questions about coverage or cost, contact your Medicare Part D plan using the number on your member ID card.
This article is for general educational purposes and is not a substitute for medical advice from a qualified healthcare professional.
Sources: FDA prescribing information and Ozempic cost and coverage information.
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